Serious - Use Alternative (1)olmesartan, perindopril. Either increases toxicity of the other by pharmacodynamic synergism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Mechanism: pharmacodynamic synergism. , Date First Available labetalol and verapamil both increase anti-hypertensive channel blocking. Use Caution/Monitor. 2017;18(9):1906. doi:10.3390/ijms18091906. As i can read in many articles online, the usual dosage is 2 to 9 grams of dried reishi mushroom per day. Use Caution/Monitor. Use Caution/Monitor. Keep taking this medication even if you feel well. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Reishi Mushroom; Shroom Tech Immune; Turmeric; Inflamation & Joints. Generally, all medications and supplements should be stored out of reach of children. Please confirm that you would like to log out of Medscape. Use Caution/Monitor.bisoprolol, valsartan. Use Caution/Monitor. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)verapamil, nadolol. Contraindicated. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Use Caution/Monitor. Monitor Closely (1)metyrapone will increase the level or effect of valsartan by Other (see comment). Minor/Significance Unknown. Minor/Significance Unknown. verapamil will increase the level or effect of hydroxyprogesterone caproate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The recommended Alpha Lipoic Acid dosage will depend on why this supplement is being used and who is taking it. verapamil will increase the level or effect of rimegepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of valsartan by Other (see comment). Mechanism: pharmacodynamic synergism. Product labeling for PO topotecan recommends avoiding concomitant use of P-gp inhibitors; the interaction with IV topotecan may be less severe but is still likely of clinical significance. erythromycin stearate will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan and tolfenamic acid both increase serum potassium. Monitor Closely (1)dofetilide will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. verapamil will increase the level or effect of fludrocortisone by P-glycoprotein (MDR1) efflux transporter. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Learn how to monitor your own blood pressure, and share the results with your doctor. No supplement is intended to treat, cure, or prevent disease. valsartan and nebivolol both increase serum potassium. Medscape Education. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. hydralazine decreases levels of pyridoxine (Antidote) by unspecified interaction mechanism. Use Caution/Monitor. Monitor Closely (1)butabarbital will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. verapamil will increase the level or effect of ziprasidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor. Stonehenge Health Dynamic Mushrooms - 100% Fruiting Bodies & Extracts - Lions Mane, Chaga, Maitake, Shiitake, Reishi - Nootropic Brain & Focus, Immune System Booster - No Mycelium -60 Veggie Capsules. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)naproxen, perindopril. Use Caution/Monitor. verapamil decreases effects of metformin by Other (see comment). aspirin decreases effects of hydralazine by pharmacodynamic antagonism. The Adequate Intake for fiber recommendations is 14 grams of fiber/1000 calories of intake. Minor (1)hydralazine decreases levels of pyridoxine by unspecified interaction mechanism. Use Caution/Monitor. verapamil will increase the level or effect of nisoldipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nifedipine and verapamil both increase anti-hypertensive channel blocking. Do not double the dose to catch up. STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. CYP3A4 inhibition decreases metabolism of tamoxifen to N-desmethyl tamoxifen (active metabolite with similar biologic activity). WebCalan, Isoptin SR: 180 mg/day PO given in morning (120 mg/day initially if patient elderly or of small stature); for desired response, may be increased to 240 mg/day, then to 360 mg/day (either 180 mg q12hr or 240 mg in morning and 120 mg in evening) siponimod, verapamil. Either increases effects of the other by pharmacodynamic synergism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Use Caution/Monitor.amiodarone will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Potassium salts may increase the hyperkalemic effects of ACE inhibitors; the effect may be the result of aldosterone suppression in patients receiving ACE inhibitors. Avoid or Use Alternate Drug. Either increases toxicity of the other by Other (see comment). verapamil will increase the level or effect of bazedoxifene/conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. May inhibit organic anion transporter polypeptides; decrease dose of angiotensin receptor blockers and monitor patients for signs and symptoms of hypotension and/or worsening renal function; if such events occur, consider further dose reduction of angiotensin receptor blocker or switching to alternative to angiotensin receptor blocker Minor (1)ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of valsartan by decreasing elimination. Use Caution/Monitor. This favored fungus is one of the most popular medicinal mushrooms, and for good reason. Use Caution/Monitor. Use Caution/Monitor. perindopril, aspirin. Avoid disopyramide administration within 48 hours before or 24 hours after verapamil administration. Monitor Closely (1)perindopril, silodosin. verapamil will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Golbidi S, Badran M, Laher I. Diabetes and Alpha Lipoic Acid. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Minor/Significance Unknown. Increased risk of neurotoxicity. . Minor (1)verapamil will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.mefenamic acid decreases effects of valsartan by pharmacodynamic antagonism. NSAIDs decrease prostaglandin synthesis. Decrease betrixaban dose to 80 mg PO once, then 40 mg PO qDay if coadministered with a P-gp inhibitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Either increases effects of the other by pharmacodynamic synergism. Amounts and Dosage. Use Caution/Monitor. Effect of interaction is not clear, use caution. Either increases toxicity of the other by Other (see comment). Monitor Closely (1)hydralazine, treprostinil. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Monitor Closely (1)perindopril, nabumetone. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvY2FsYW4tc3ItaXNvcHRpbi1zci12ZXJhcGFtaWwtMzQyMzgw, View explanations for tiers and Use Caution/Monitor. Reviewed in the United States on November 9, 2022. Cardiac dysrhythmic effects may be additive. Either increases effects of the other by decreasing renal clearance. . Dietary fiber intake may help lower blood pressure. Monitor Closely (1)enoxaparin increases toxicity of valsartan by Other (see comment). verapamil will increase the level or effect of pexidartinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Most Minor/Significance Unknown. If coadministration with strong or moderate CYP3A4 inhibitors is unavoidable, reduce pexidartinib dose (refer to drug monograph dosage modifications). Use Caution/Monitor. verapamil will increase the level or effect of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)perindopril increases effects of exenatide injectable solution by Other (see comment). Use Caution/Monitor. Monitor Closely (1)aspirin/citric acid/sodium bicarbonate decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. Mitral valve rheumatic heart disease. Either increases toxicity of the other by pharmacodynamic synergism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. valsartan, insulin inhaled. Consider decreasing dosage of antihypertensive agent. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. aspirin decreases effects of valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Risk of acute hypotension, renal insufficiency. Minor/Significance Unknown. Monitor Closely (2)verapamil will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Exaggerated first dose hypotensive response. Minor/Significance Unknown. Use Caution/Monitor. valsartan increases effects of insulin lispro by unspecified interaction mechanism. Risk of fetal compromise if given during pregnancy. Sympathomimetics can antagonize the activity of some antihypertensive agents. Use Caution/Monitor. Comment: OATP1B1 inhibitors may increase risk of myopathy. Modify Therapy/Monitor Closely. verapamil will increase the level or effect of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. See specific ivacaftor-containing product for precise dosage modification. salsalate decreases effects of valsartan by pharmacodynamic antagonism. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Monitor blood pressure and adjust dose of antihypertensive agent as needed. valsartan and propranolol both increase serum potassium. valsartan and nabumetone both increase serum potassium. Monitor for adverse reactions. Use Caution/Monitor. Use Caution/Monitor. Minor (1)ofloxacin will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. celecoxib decreases effects of hydralazine by pharmacodynamic antagonism. Monitor Closely (3)valsartan, celecoxib. Minor/Significance Unknown. perindopril, etodolac. Ca Channel Blockers interfere w/Ach release from prejunctional axon. Monitor blood pressure and adjust dose of antihypertensive agent as needed. Serious - Use Alternative (1)verapamil and cyclobenzaprine both increase serotonin levels. Avoid or Use Alternate Drug. Sympathomimetics can antagonize the activity of some antihypertensive agents. I have to reduce taking one pill a day. Additive hypotensive effects. Serious - Use Alternative (1)valsartan, quinapril. Use Caution/Monitor. What Happens If I Take Too Much Beta-Glucan? verapamil will increase the level or effect of posaconazole by P-glycoprotein (MDR1) efflux transporter. verapamil will increase the level or effect of sirolimus by P-glycoprotein (MDR1) efflux transporter. perindopril, doxazosin. Observe for possible additive hypotensive effects during concomitant use. ozanimod increases toxicity of verapamil by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. voriconazole will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. aldesleukin increases effects of hydralazine by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Monitor Closely (3)verapamil will increase the level or effect of cortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. verapamil will increase the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan and aceclofenac both increase serum potassium. All material on this website is protected by copyright, Copyright 1994-2022 by WebMD LLC. metyrapone will increase the level or effect of valsartan by Other (see comment). Monitor more closely for signs of venetoclax toxicities. Either increases effects of the other by pharmacodynamic synergism. Minor (1)verapamil will increase the level or effect of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. NSAIDs decrease prostaglandin synthesis. Monitor blood pressure and adjust dose of antihypertensive agent as needed. Monitor Closely (1)berotralstat will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. valsartan increases and chlorthalidone decreases serum potassium. Serious - Use Alternative (1)verapamil will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For example, those in the oat supplementation group lost about 1 kilogram more weight (about 2 pounds). verapamil will increase the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Furthermore, how you take Alpha Lipoic Acid and which form of the supplement you use can affect your results. Use Caution/Monitor. The side effects should wear off over time, but slowly introducing it can help prevent this. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. After discontinuing the CYP3A4 inhibitor for 3 elimination half-lives, may resume previous pemigatinib dose. Monitor Closely (1)perindopril increases toxicity of metformin by unspecified interaction mechanism. Your recently viewed items and featured recommendations, Select the department you want to search in. nicardipine and verapamil both increase anti-hypertensive channel blocking. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Monitor Closely (1)verapamil, nitroglycerin sublingual. Monitor Closely (1)perindopril increases effects of glyburide by pharmacodynamic synergism. hydralazine, bretylium. perindopril, silodosin. perindopril, entecavir. Minor/Significance Unknown. valsartan increases effects of albiglutide by Other (see comment). Enhanced antiplatelet activity. Use Caution/Monitor.quinidine will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor. aspirin rectal, perindopril. Use Caution/Monitor. Contraindicated. Minor/Significance Unknown. Minor/Significance Unknown. Contraindicated. Monitor Closely (1)topiramate will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for increased risk of QTc interval prolongation.Serious - Use Alternative (1)ivosidenib will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (2)verapamil will increase the level or effect of erythromycin ethylsuccinate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. Monitor Closely (1)miconazole vaginal will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: pharmacodynamic antagonism. Monitor Closely (1)hydralazine, iloprost. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. acebutolol and verapamil both increase anti-hypertensive channel blocking. Risk of acute hypotension, renal insufficiency. Either increases toxicity of the other by Other (see comment). Monitor Closely (1)verapamil will increase the level or effect of imatinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Applies only to oral form of both agents. Heart Failure (Off-label) Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. WARNING: Perindopril can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Monitor Closely (1)verapamil, sodium sulfate/?magnesium sulfate/potassium chloride. perindopril, sulindac. Monitor Closely (1)valsartan and salicylates (non-asa) both increase serum potassium. Exaggerated first dose hypotensive response. Avoid or Use Alternate Drug. Consider decreasing dosage of antihypertensive agent. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. Minor/Significance Unknown. Minor/Significance Unknown. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Use Caution/Monitor. This amount was taken in divided doses daily for a maximum of four years. Monitor Closely (1)verapamil will increase the level or effect of acalabrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. piroxicam decreases effects of valsartan by pharmacodynamic antagonism. Monitor Closely (1)timolol and verapamil both increase anti-hypertensive channel blocking. verapamil will increase the level or effect of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. After discontinuing the inhibitor for 3-5 elimination half-lives, resume previous encorafenib dose. Monitor for hypertension with concomitant use. Monitor Closely (1)verapamil increases levels of rifaximin by P-glycoprotein (MDR1) efflux transporter. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Use Caution/Monitor. istradefylline will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. Risk of hypertension. Comment: Theoretically, shepherd's purse may interfere with BP control. Use Caution/Monitor. felodipine and verapamil both increase anti-hypertensive channel blocking. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Use Caution/Monitor. Lonafarnib is a sensitive CYP3A4 substrate. Use Caution/Monitor. Buy Naturealm Sacred 7 - Mushroom Extract Powder 8 oz - Chaga, Cordyceps, Lion's Mane, Maitake, Reishi, Shiitake & Turkey Tail - Organic Herbal Nootropic Supplement - Focus, Energy & Mental Performance on Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. pharmacodynamic antagonism. Ca Channel Blockers interfere w/Ach release from prejunctional axon. Minor/Significance Unknown. Use Caution/Monitor.sotalol, valsartan. Modify Therapy/Monitor Closely. and formulary information changes. If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are achieved. Coadministration of verapamil and cyclosporine may increase plasma concentrations of either drugs. butalbital will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)sotalol and verapamil both increase anti-hypertensive channel blocking. May induce SLE-type syndrome (usually at >200 mg/day); instruct patients to report joint/chest pain or fever; discontinue therapy unless benefits outweigh risks; steroid therapy may be necessary long-term ibuprofen decreases effects of hydralazine by pharmacodynamic antagonism. hydralazine, xylometazoline. sulfasalazine decreases effects of perindopril by pharmacodynamic antagonism. Serious - Use Alternative (1)verapamil will increase the level or effect of talazoparib by P-glycoprotein (MDR1) efflux transporter. atazanavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)acebutolol, valsartan. Use Caution/Monitor. Modify Therapy/Monitor Closely. verapamil will increase the level or effect of ritonavir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor heart rate in patients receiving concomitant verapamil and clonidine. Verapamil also inhibits P-gp activity, which can further increase rivaroxaban serum levels; since both pathways of rivaroxaban elimination are affected, patients with renal impairment receiving rivaroxaban with drugs that are combined P-gp and moderate CYP3A4 inhibitors may increase exposure compared to patients with normal renal function; monitor for bleeding. Risk of hypotension. verapamil will increase the level or effect of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Use Caution/Monitor. Either increases toxicity of the other by unspecified interaction mechanism. Monitor Closely (1)valsartan and acemetacin both increase serum potassium. timolol and verapamil both increase anti-hypertensive channel blocking. Monitor Closely (1)phenobarbital will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. After discontinuation of the strong or moderate CYP3A4 inhibitor for 3 elimination half-lives, resume selumetinib dose that was taken before initiating the inhibitor. verapamil will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. NSAIDs decrease prostaglandin synthesis. Contraindicated. Monitor Closely (1)hydralazine, phendimetrazine. Monitor Closely (1)verapamil will increase the level or effect of risperidone by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (2)verapamil will increase the level or effect of estropipate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. DePaul University does not discriminate on the basis of race, color, ethnicity, religion, sex, gender, gender identity, sexual orientation, national origin, age, marital status, pregnancy, parental status, family relationship status, physical or mental disability, military status, genetic information or other status protected I am excited to add the benefits of mushrooms to my health routine. Comment: OATP1B1 inhibitors may increase risk of myopathy. Use Caution/Monitor. You can support a healthy immune system by getting enough sleep, exercising, eating a healthy diet, and generally taking care of yourself. Either increases toxicity of the other by Other (see comment). valsartan, insulin degludec/insulin aspart. Risk of hypotension. Sympathomimetics can antagonize the activity of some antihypertensive agents. hydralazine increases effects of metoprolol by pharmacodynamic synergism. Otherwise, call a poison control center right away. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. erythromycin lactobionate will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Both drugs decrease blood glucose. Use Caution/Monitor. How much Reishi per day also highly depends upon the underlying condition for which it is being taken. Monitor Closely (2)verapamil will increase the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. verapamil will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May advise patients to limit or minimize the intake of caffeinated products to minimize caffeine-related side effects. Use Caution/Monitor. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: aliskiren, gold injections, lithium, sacubitril, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone).Some products have ingredients that could raise your blood pressure or worsen your heart failure. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Keep taking this medication even if you feel well. Comment: With concomitant use of mTOR inhibitors, consider appropriate dose reductions of both medications. Sympathomimetics can antagonize the activity of some antihypertensive agents. If coadministration with certain P-gp inhibitors (ie, amiodarone, carvedilol, clarithromycin, itraconazole, verapamil) cannot be avoided, reduce talazoparib dose to 0.75 mg qDay. Use Caution/Monitor. NOTES: No monograph available at this time. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Additive hypotensive effects. , Manufacturer Avoid or Use Alternate Drug. Monitor Closely (1)perindopril, bumetanide. Monitor Closely (1)valsartan and trimethoprim both increase serum potassium. Didn't work for me. Either increases effects of the other by serotonin levels. DVT/PE treatment: Decrease dose to 30 mg PO once daily. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)verapamil will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Each subcommittee will meet and consider all reviews. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. Cautions. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Talk to your doctor if you are using marijuana (cannabis).Too much sweating, diarrhea, or vomiting may cause dehydration and increase your risk of lightheadedness. ibuprofen, perindopril. Use Caution/Monitor. Use Caution/Monitor. Closely monitor for increased adverse reactions and modify dose of darolutamide as needed when coadministered with drugs that are both P-gp and strong or moderate CYP3A4 inhibitors. Use Caution/Monitor. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Use Caution/Monitor. Monitor Closely (1)verapamil will increase the level or effect of rimegepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Comment: May result in renal function deterioration, particularly with high doses of aspirin,in elderly or volume depleted individuals.Serious - Use Alternative (1)aspirin, perindopril. valsartan and acebutolol both increase serum potassium. Mechanism: pharmacodynamic synergism. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Minor (1)lornoxicam decreases effects of perindopril by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Comment: Verapamil levels may incr or decr, due to contradictory effects of tipranavir on hepatic CYP3A4 and P glycoprotein.tipranavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: pharmacodynamic antagonism. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)verapamil will increase the level or effect of colchicine by Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. verapamil will increase the level or effect of itraconazole by P-glycoprotein (MDR1) efflux transporter. verapamil, atenolol. Avoid or Use Alternate Drug. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Use Caution/Monitor. Beta-glucan may prevent cholesterol absorption from food, helping to lower blood cholesterol levels. Minor/Significance Unknown. Minor/Significance Unknown. perindopril, protein a column. Modify Therapy/Monitor Closely. Mechanism: pharmacodynamic antagonism. perindopril, spironolactone. Cyclosporine and valsartan both increase the risk of hyperkalemia and nephrotoxicity. Monitor Closely (1)xipamide increases effects of verapamil by pharmacodynamic synergism. Some people have also reported hair loss and hypothyroidism, especially with high dosages. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure, simvastatin will increase the level or effect of valsartan by Other (see comment). Monitor Closely (2)verapamil will increase the level or effect of duvelisib by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)hydralazine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. verapamil will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. verapamil will increase the level or effect of saquinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. NSAIDs decrease prostaglandin synthesis. For best results, take 20-30 min before a meal with an 8oz glass of water or as directed by your healthcare professional. Monitor Closely (2)verapamil will increase the level or effect of maraviroc by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Comments of primary and secondary reviewers will be sent to all members of the relevant subcommittee. bosentan will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)zafirlukast will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan increases and methyclothiazide decreases serum potassium. Use Caution/Monitor. Monitor Closely (1)hydralazine, fenfluramine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Monitor Closely (1)lurasidone increases effects of perindopril by Other (see comment). parecoxib decreases effects of hydralazine by pharmacodynamic antagonism. Monitor Closely (1)perindopril increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. The risk of significant hypotension and/or bradycardia during therapy with alfentanil may be increased in patients receiving calcium-channel blockers. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Not a fan of this serving scheme for supplements. Adding mushrooms to your favorite stir frys, pastas, and eggs can give you an extra melatonin boost. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, meloxicam. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Am J Lifestyle Med. Use Caution/Monitor. Look for whole grains as close to their natural states as possible. Minor/Significance Unknown. Avoid or Use Alternate Drug. clonidine, verapamil. Observe for possible additive hypotensive effects during concomitant use. Use Caution/Monitor.nafcillin decreases levels of verapamil by increasing metabolism. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. verapamil will increase the level or effect of deflazacort by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Comments of primary and secondary reviewers will be sent to all members of the relevant subcommittee. hydralazine decreases levels of pyridoxine by unspecified interaction mechanism. perindopril increases effects of exenatide injectable suspension by Other (see comment). 2010diovan-hct-valsartan-hydrochlorothiazide-342341Drugs, encoded search term (valsartan (Diovan)) and valsartan (Diovan), FDA Fast-Tracks Approval of Generic Valsartan in Wake of Recalls, FDA Permits Temporary Distribution of Tainted Losartan, Want to Save a Billion Dollars? Avoid or Use Alternate Drug. hydralazine increases effects of celiprolol by pharmacodynamic synergism. Beta-glucans are one type of fiber found most commonly in oats and barley. Consider decreasing the cilostazol dose to 50 mg twice a day. verapamil increases levels of afatinib by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (2)verapamil will increase the level or effect of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)valsartan and potassium acid phosphate both increase serum potassium. Avoid or Use Alternate Drug.verapamil, sirolimus. cobicistat will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. dantrolene, verapamil. Contraindicated. perphenazine increases effects of perindopril by unspecified interaction mechanism. Use Caution/Monitor. stiripentol will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. perindopril, asenapine. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. valsartan and choline magnesium trisalicylate both increase serum potassium. Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with strong CYP inhibitors may require a decreased initial dose of 0.5 mg PO TID; monitor for signs of hypotension and reduce dose if needed. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. verapamil increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tizanidine increases effects of perindopril by pharmacodynamic synergism. Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials. perindopril and canagliflozin both increase serum potassium. Use Caution/Monitor. Do not substitute tablets with capsules. Monitor Closely (1)verapamil will increase the level or effect of cilostazol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. valsartan and parecoxib both increase serum potassium. But tart cherry juice can be high in sugar so it's best to limit the amount you drink to about 4 oz to 6 oz, or no more than 8 oz per day in the context of an overall lower-sugar diet. Doses used in studies range from 2 to 6 grams taken orally daily for up to 12 weeks for oat beta-glucan. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Monitor Closely (2)propranolol, valsartan. Our products are formulated in the USA and produced in a lab that follows strict Good Manufacturing Practices (cGMP). Serious - Use Alternative (1)valsartan, benazepril. Monitor Closely (1)atenolol and verapamil both increase anti-hypertensive channel blocking. Use Caution/Monitor. Monitor Closely (1)avanafil increases effects of valsartan by pharmacodynamic synergism. Int J Mol Sci. Reviewed in the United States on July 9, 2022. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Enhanced antiplatelet activity. While a food-first approach for fiber intake is preferred, supplementation is also an option. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, liver disease.This drug may make you dizzy. , ASIN Decrease deflazacort dose to one-third of the recommended dose if coadministered with moderate or strong CYP3A4 inhibitors. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.verapamil will increase the level or effect of bazedoxifene/conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Additive hypotensive effects. Use Caution/Monitor. Either decreases toxicity of the other by unknown mechanism. Use Caution/Monitor.verapamil increases toxicity of doxorubicin liposomal by decreasing metabolism. Use Caution/Monitor. verapamil will increase the level or effect of prednisolone by P-glycoprotein (MDR1) efflux transporter. Minor (1)verapamil will increase the level or effect of antipyrine by affecting hepatic enzyme CYP1A2 metabolism. If it is near the time of the next dose, skip the missed dose. Concomitant use of fostamatinib may increase concentrations of P-gp substrates. Not a fan of this serving scheme for supplements. If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are achieved. Risk of hypotension. Either increases toxicity of the other by unspecified interaction mechanism. By clicking send, you acknowledge that you have permission to email the recipient with this information. This effect was not observed with istradefylline 20 mg/day. Serious - Use Alternative (1)verapamil will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. aspirin/citric acid/sodium bicarbonate decreases effects of hydralazine by pharmacodynamic antagonism. pharmacodynamic antagonism. Use Caution/Monitor.verapamil will increase the level or effect of lapatinib by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Use Caution/Monitor. verapamil, mavacamten. Use Caution/Monitor. TCA level may be increased.Minor (1)verapamil increases levels of imipramine by decreasing metabolism. pharmacodynamic antagonism. Monitor Closely (2)verapamil will increase the level or effect of oliceridine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan and diclofenac both increase serum potassium. Monitor Closely (2)elagolix will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. Potassium salts may increase the hyperkalemic effects of ARBs; the effect may be the result of aldosterone suppression in patients receiving ARBs. Use Caution/Monitor. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvYWNlb24tcGVyaW5kb3ByaWwtMzQyMzIw, View explanations for tiers and Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. brimonidine increases effects of valsartan by pharmacodynamic synergism. Monitor Closely (1)perindopril, terazosin. Use Caution/Monitor. Monitor Closely (1)amifostine, perindopril. Use Caution/Monitor. Monitor for increased bradycardia, hypotension, or dizziness. Use Caution/Monitor. Minor (1)verapamil increases levels of nortriptyline by decreasing metabolism. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. WebOur Commitment to Anti-Discrimination. Avoid coadministration of avapritinib with strong CYP3A4 inhibitors. verapamil will increase the level or effect of edoxaban by P-glycoprotein (MDR1) efflux transporter. verapamil will increase the level or effect of imipramine by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). valsartan, insulin inhaled. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Serious - Use Alternative (1)verapamil will increase the level or effect of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Search our drug database for comprehensive prescription and patient information on 24,000 drugs online. Risk of fetal compromise if given during pregnancy. Minor (1)creatine, perindopril. Monitor Closely (2)lapatinib will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor (2)verapamil will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. valsartan and sotalol both increase serum potassium. However, there are recommendations for total fiber intake, and many Americans do not get enough fiber in their diet. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. Monitor Closely (1)hydralazine increases effects of bisoprolol by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of valsartan by Other (see comment). Monitor Closely (1)perindopril, aspirin. verapamil will increase the level or effect of etoposide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)amlodipine and verapamil both increase anti-hypertensive channel blocking. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Coadministration may result in a significant decrease in renal function. Minor/Significance Unknown. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. valsartan and ibuprofen both increase serum potassium. salicylates (non-asa) decreases effects of hydralazine by pharmacodynamic antagonism. Monitor Closely (1)DHEA, herbal will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by unspecified interaction mechanism. shepherd's purse, valsartan. Use Caution/Monitor. Closely monitor for increased adverse reactions and modify dose of darolutamide as needed when coadministered with drugs that are both P-gp and strong or moderate CYP3A4 inhibitors. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. This fiber can be found in oats, barley, and some mushrooms or as a supplement. Mechanism: pharmacodynamic antagonism. Serious - Use Alternative (1)valsartan, fosinopril. Either increases toxicity of the other by unspecified interaction mechanism. Risk of fetal compromise if given during pregnancy. Contraindicated. Monitor Closely (1)verapamil will increase the level or effect of ivermectin by P-glycoprotein (MDR1) efflux transporter. Minor (1)verapamil increases levels of protriptyline by decreasing metabolism. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Monitor Closely (1)valsartan increases effects of insulin NPH by unspecified interaction mechanism. If coadministration is necessary, decrease colchicine dose or frequency as recommended in prescribing information. Monitor Closely (1)ketoconazole will increase the level or effect of valsartan by Other (see comment). hydralazine, linezolid. Minor/Significance Unknown. Avoid or Use Alternate Drug. Verified Purchase. Monitor Closely (1)verapamil will increase the level or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Use Caution/Monitor. verapamil increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)valsartan increases effects of insulin detemir by unspecified interaction mechanism. Modify Therapy/Monitor Closely. My package just arrived and I am impressed with the fast delivery and the packaging. Minor (1)hydralazine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. perindopril, ibuprofen IV. Use Caution/Monitor. naproxen decreases effects of valsartan by pharmacodynamic antagonism. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Minor/Significance Unknown. Avoid coadministration of ivabradine with moderate CYP3A4 inhibitors. verapamil increases levels of vilazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor (1)verapamil increases levels of maprotiline by decreasing metabolism. Use Caution/Monitor. nesiritide, perindopril. Monitor patients already on buprenorphine subdermal implant who require newly-initiated treatment with CYP3A4 inhibitors for signs and symptoms of overmedication. Monitor Closely (1)diflunisal decreases effects of hydralazine by pharmacodynamic antagonism. After discontinuation of the strong or moderate CYP3A4 inhibitor for 3 elimination half-lives, resume selumetinib dose that was taken before initiating the inhibitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. pharmacodynamic antagonism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. CYP3A4 inhibition decreases metabolism of tamoxifen to N-desmethyl tamoxifen (active metabolite with similar biologic activity). Avoid concomitant use of verapamil and lovastatin if possible. Avoid or Use Alternate Drug. Use Caution/Monitor. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. Mushrooms treated with UV lamps can produce even higher amounts of vitamin D. Mushrooms. Use Caution/Monitor. It works by relaxing blood vessels so blood can flow more easily. Use Caution/Monitor. Avoid or Use Alternate Drug. verapamil will increase the level or effect of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Icatibant has potential to have a pharmacodynamic interaction with ACE inhibitors where it may attenuate the antihypertensive effect of ACE inhibitors. prochlorperazine increases effects of perindopril by unspecified interaction mechanism. Use Caution/Monitor. verapamil will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.Minor (1)verapamil will increase the level or effect of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. A: Generally acceptable. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of ARBS with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. This product came in the original box and safety sealed. Minor/Significance Unknown. Limit alcoholic beverages. Use Caution/Monitor. Monitor Closely (1)methylphenidate transdermal decreases effects of perindopril by anti-hypertensive channel blocking. Use Caution/Monitor. Use Caution/Monitor. hydralazine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)lovastatin will increase the level or effect of valsartan by Other (see comment). Use Caution/Monitor. If intolerable adverse effects occur when coadministered with moderate CYP3A4 inhibitors, reduce daily dose to 20 mg. verapamil, vortioxetine. Use Caution/Monitor. Monitor renal function periodically. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (2)verapamil will increase the level or effect of estrogens conjugated synthetic by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor (1)fluphenazine increases effects of perindopril by unspecified interaction mechanism. Avoid or Use Alternate Drug. Minor/Significance Unknown. apalutamide will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Ca Channel Blockers interfere w/Ach release from prejunctional axon. Consult your doctor for more details.Lab and/or medical tests (such as kidney function, potassium levels) should be done while you are taking this medication. Modify Therapy/Monitor Closely. When taken from supplemental sources, researchers have found that ALA may have several important effects on the body. It is also sold as a supplement. Use Caution/Monitor. Modify Therapy/Monitor Closely. Risk of hypotension. commonly, these are "preferred" (on formulary) brand drugs. Contraindicated. Use Caution/Monitor. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. Modify Therapy/Monitor Closely. valsartan and naproxen both increase serum potassium. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. moxisylyte and verapamil both increase anti-hypertensive channel blocking. Monitor blood pressure and adjust dose of antihypertensive agent as needed. Do not substitute tablets with capsules. Sympathomimetics can antagonize the activity of some antihypertensive agents. This means that the content of some products may differ from what is specified on their product labels. Enhanced antiplatelet activity. Sympathomimetics can antagonize the activity of some antihypertensive agents. Either increases toxicity of the other by unspecified interaction mechanism. Modify Therapy/Monitor Closely. Monitor Closely (1)sulfasalazine decreases effects of hydralazine by pharmacodynamic antagonism. May induce SLE-type syndrome (usually at >200 mg/day); instruct patients to report joint/chest pain or fever; discontinue therapy unless benefits outweigh risks; steroid therapy may be necessary long-term Save my name, email, and website in this browser for the next time I comment. eprosartan, perindopril. Corpina explains that determining the correct dosage of magnesium depends on several things, including what your symptoms are, how magnesium depleted you are, and the kind of magnesium supplement that you are taking.. Use Caution/Monitor. Reduce ivacaftor dose if coadministered with moderate CYP3A4 inhibitors. It should be consumed on an empty stomach to maximize absorption from the gut. NSAIDs decrease prostaglandin synthesis. Monitor Closely (1)acebutolol and verapamil both increase anti-hypertensive channel blocking. This document does not contain all possible drug interactions. Monitor Closely (1)perindopril, etodolac. Mechanism: pharmacodynamic synergism. Other (see comment). Use Caution/Monitor. Although beta-glucan is generally considered safe, there may be a few side effects. aspirin rectal decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor.atenolol, valsartan. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, celecoxib. Corpina explains that determining the correct dosage of magnesium depends on several things, including what your symptoms are, how magnesium depleted you are, and the kind of magnesium supplement that you are taking.. Serious - Use Alternative (1)hydralazine, pretomanid. NSAIDs decrease prostaglandin synthesis. Monitor Closely (2)verapamil will increase the level or effect of conjugated estrogens, vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)trimethoprim and perindopril both increase serum potassium. Avoid or Use Alternate Drug. Each drug may cause hypotension. valsartan decreases effects of synthetic human angiotensin II by pharmacodynamic antagonism. Use Caution/Monitor.verapamil decreases levels of eslicarbazepine acetate by increasing metabolism. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required. Make sure all your doctors know which medicines you are using. Amount Per Serving - % Daily Value 30 Day Supply. everolimus will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. deferasirox will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. verapamil will increase the level or effect of deflazacort by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. It should be consumed on an empty stomach to maximize absorption from the gut. Mechanism: pharmacodynamic synergism. Alcohol or marijuana (cannabis) can make you more dizzy. Monitor Closely (1)hydralazine will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension. Monitor Closely (2)atazanavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)mefloquine increases levels of verapamil by decreasing metabolism. Monitor Closely (1)lornoxicam decreases effects of hydralazine by pharmacodynamic antagonism. hydralazine, benzphetamine. Monitor Closely (1)tucatinib will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Risk of hyperkalemia. Minor/Significance Unknown. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Increased risk of orthostatic hypotension. Monitor glycemic control especially during the first month of treatment with an ACE inhibitor. pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Monitor patients for changes in glycemic control. Looking at studies conducted over the previous 13 years, the report's authors determined that oat-derived beta-glucan may significantly reduce levels of total and low-density lipoprotein (LDL) or "bad" cholesterol. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. For the sake of this example i will consider a 5 gram dose as the average. verapamil increases effects of willow bark by unknown mechanism. azilsartan, perindopril. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Monitor Closely (3)valsartan, ibuprofen IV. Monitor Closely (1)aldesleukin increases effects of verapamil by pharmacodynamic synergism. 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