By reducing polyps, the study suggests multivitamins might also lower colorectal cancer risk. FOIA Inverse associations were observed in both men and women but were restricted to colon cancer. The CUP included evidence from total dairy, milk, and cheese intake and found an association between higher milk and diary consumption and decreased risk of all colorectal cancer sub-types4 However, the evidence available for cheese was not as strong as the other exposures.4 The panel also found that increasing dietary calcium intake by 200 mg per day decreased the risk of colon cancer by 6%. Our website services, content, and products are for informational purposes only. Signs and symptoms of colon cancer include: A persistent change in your bowel habits, including diarrhea or constipation or a change in the consistency of your stool. doi: 10.1093/advances/nmy114. The 2015-2020 Dietary Guidelines for Americans recommend consuming low-fat and fat-free dairy products as part of a healthy diet.6. PMC The results of a Cohort study in Swedish women showed that women who consumed 4 servings of high-fat dairy foods per day (including whole milk, full-fat cultured milk, cheese, cream, sour cream, and butter) had a multivariate rate ratio of colorectal cancer of 0.59 (95% CI: 0.44, 0.79; P for trend = 0.002) when compared to women who consumed . Some types of dairy may have protective effects. Bermejo LM, Lpez-Plaza B, Santurino C, Cavero-Redondo I, Gmez-Candela C. Adv Nutr. 2017 Aug 1;28(8):1788-1802. doi: 10.1093/annonc/mdx171. [3] Both liver and breast cancer are among the most common types of cancer in China, accounting for around 393,000 and 368,000 new cancer cases each year respectively. Flow of information through the different phases of the identification and selection of relevant studies examining the associations between the consumption of dairy products and the risk of CRC in adults. Dairy products such as milk, cheese, ice cream, yogurt, and sherbet contain lactose. Suppress proliferation, promote terminal cell differentiation and induce apoptosis of colorectaltumourcells; Bind secondary bile acids (bile acids which are formed from the action of intestinal bacteria on bile acids synthesized by the liver) or ionized fatty acids so as to inhibit their ability to modify coloniccells. In general, vegetarians avoid eating meat, but do eat dairy products or certain dairy products such as eggs. 2015 2020. Barrubs L, Babio N, Becerra-Toms N, Rosique-Esteban N, Salas-Salvad J. Adv Nutr. 2022 Oct 18;14(20):4362. doi: 10.3390/nu14204362. In addition to calcium, lactic acid-producing bacteria may also protect against colorectal cancer, while the casein and lactose in milk may increase calcium bioavailability. in Nutrition and is currently working towards a Master of Science (M.Sc.) Cohen SS, Bylsma LC, Movva N, Alexander DD. Here are 5 proven benefits of BCAAs. The purpose of these recommendations is to ensure adequate intake of minerals, such as calcium and potassium. 2022 Aug 27;22(1):1625. doi: 10.1186/s12889-022-14042-7. $500 $250 $100 $50 Donate Now Tags Public Health Sciences Emily White STTR cancer John D Potter Fred Hutch The researchers applied camel milk lactoferrin to HCT-116 colon cancer cells and found that high concentrations of between 3 mg/ml and 5 mg/ml demonstrated a 56% decline of growth after two days. It has been shown to inhibit proliferation and induce differentiation intumourcell lines.7, In animal models,lactoferrin, a milk protein, has been shown to suppress carcinogenesis in the colon and other organs. Reduce your alcohol intake. Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies. This article reviews the evidence linking dairy products with cancer, looking at both sides of the argument. Cheese consumption was inversely associated with the risk of CRC (RR: 0.85; 95% CI: 0.76, 0.96) and proximal colon cancer (RR: 0.74; 95% CI: 0.60, 0.91). The .gov means its official. The latest report fromthe World Cancer Research Fund (WCRF) and the AICR, states that consuming dairy products decreases the risk of colorectal cancer. 10 of the Best Protein Bars to Fuel Your Day, According to Testers and Dietitians, Pepsi Milk: What Health Experts Think Of the Dirty Soda Viral Drink, 5 Proven Benefits of BCAAs (Branched-Chain Amino Acids), 'Green' Mediterranean Diet Reduces Twice As Much Fat As Mediterranean Diet. Yet, at the same time, dairy products may reduce the risk of colorectal cancer. This may be due to several bioactive compounds found in milk. Colorectal cancer. Diet, Nutrition, Physical Activity and Cancer:aGlobal Perspective, Continuous Update Project Expert Report 2018. The summary RR was 0.83 (95% CI [confidence interval]: 0.78-0.88, I2=25%) per 400 g/day of total dairy products, 0.91 (95% CI: 0.85-0.94, I2=0%) per 200 g/day of milk intake and 0.96 (95% CI: 0.83-1.12, I2=28%) per 50 g/day of cheese. Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort. Larsson SC et al. Cancer Council supports the Australian Dietary Guidelines, which encourage adults to eat at least two and a half serves of dairy foods (milk, cheese and yoghurt) each day and to choose reduced fat varieties of dairy foods where possible. Lamprecht SA and Lipkin M.Chemoprevention of colon cancer by calcium, vitaminD and folate: molecular mechanisms. The School of Human EcologyThe University of Texas at Austin 200 W 24th Street, Stop A2700Austin, Texas 78712-1247, General Inquiries: (512) 471-0165 Fax: (512) 471-5630 Advising Email, Copyright 2015School of Human EcologyCollege of Natural SciencesThe University of Texas at Austin, Web Privacy PolicyWeb Accessibility Policy. Bookshelf Asfari MM, Hamid O, Sarmini MT, Kendrick K, Pappoppula LP, Sifuentes H, Sridhar S. Cureus. Consumption of dairy products and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). About 26,800 Canadians were diagnosed with colorectal cancer in 2017.1 It is the secondmost commonly diagnosedcancer in Canada (excluding non-melanoma skin cancers). Where-as other compounds such as IGF-1 and phosphorous may have negative effects. Calcium may protect against colorectal cancer, with evidence for several plausible mechanisms. Regular . There was no association between dairy intake and colorectal cancer, prostate cancer, or any other type of cancer investigated. Accessibility 26-Jun-2002 - Last updated on 19-Jul-2008 at 13:58 GMT . Let food be thy medicine: the role of diet in colorectal cancer: a narrative review. Careers. It is one of the most common types of cancer in the world (1). Current evidence suggests that dairy consumption may help protect against colorectal cancer development. 8600 Rockville Pike High-fat meats, including fried chicken with skin, duck, hamburgers, bacon, ham, sausage, hot . Bethesda, MD 20894, Web Policies Overall, the evidence indicates that dairy products have no effects on breast cancer (34, 35, 36). The summary RR was 0.83 (95% CI [confidence interval]: 0.78-0.88, I2=25%) per 400 g/day of total dairy products, 0.91 (95% CI: 0.85-0.94, I2=0%) per 200 g/day of milk intake and 0.96 (95% CI: 0.83-1.12, I2=28%) per 50 g/day of cheese. The researchers also found that vegetarians had 22% lower risk of colorectal cancer compared to meat-eaters. For each 50g/day intake, the risk increased by 12% and 17% respectively. 8600 Rockville Pike 2020 Jul 1;11(4):1055-1057. doi: 10.1093/advances/nmaa071. In fact, some studies indicate that dairy products, excluding milk, may have protective effects (37). Effects of Huhuang Burn Liniment on wound healing and changes in IL-10 and MMP-9 levels in patients with mixed hemorrhoids. Int J Mol Sci. A number of research studies suggest that people who consume a lot of milk and other dairy products have a somewhat lower risk of developing colon cancer than those who don't. But many people avoid or minimize dairy consumption because they are "lactose intolerant," meaning they have difficulty digesting lactose a sugar found in dairy . Milk is a complex fluid containing a huge variety of bioactive compounds. sharing sensitive information, make sure youre on a federal Unable to load your collection due to an error, Unable to load your delegates due to an error. NutriNews will not only help you stay up-to-date on the latest research and scientific data related to milk products, it will be your source for upcoming events, such as webinars and symposiums. 2013 Oct;98(4):1066-83. doi: 10.3945/ajcn.113.059030. Some of them may protect against cancer, while others may have adverse effects. Animal-based proteins, such as fish, poultry, and dairy, may also be included. Guilt-Free Ice Cream Is Trending, but Is It Actually Healthy? Some studies indicate that dairy may protect against cancer, while others suggest that dairy may increase cancer risk. Keep in mind that most of the available evidence is based on observational studies, which provide suggestive evidence but not definite proof. While early detection is a key component, consider talking to your doctor about these top colon cancer-fighting foods as well. 3.Aune D, chan DS, Vieira AR, et al. doi: 10.1093/advances/nmy119. Summary estimates (RRs for cohort studies and ORs for case-control studies, with the corresponding 95% CIs; log scale) examining the associations between the consumption of dairy products and the risk of CRC. 2007;86:1722-1729. Selenium-rich foods include sunflower seeds, mushrooms, garlic, onions, Brazil nuts, whole grains, and fish like salmon, tuna, sardines, and halibut. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Certain components of dairy foods such as probiotic content, calcium, vitamin D, and CLA may all have protective effects. In December 2002, I was concerned because I hadn't had a bowel movement in two weeks. Not a health professional? We conducted a systematic review and meta-analysis to clarify the shape of the dose-response relationship between dairy products and colorectal cancer risk. Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project. The relationship between dairy consumption and colorectal cancer risk has been extensively investigated, and it has been hypothesized that dairy products including calcium, vitamin D, milk lipids, and probiotics can prevent the occurrence of colorectal cancer ( 3-6 ). Available at dietandcancerreport.org. Federal government websites often end in .gov or .mil. Is Butter a Dairy Product, and Does It Contain Lactose? Crit Rev Food SciNutr2012;52:488-513. Calcium is known to help combat the risk of colon cancer, but recent research in the US has shown that low fat dairy foods are just as effective as calcium supplements. The real danger may be the consumption of mass-produced milk and saturated fat during your teens. Copyright American Society for Nutrition 2019. In this post I want to look at what exactly makes the research confusing at first glance, look at the research around colon cancer, gastric cancers, postate and rbeast cancer, as well as try to come up with a workable plan to lower risk overall. Several biological mechanisms may explain the protective effect of calcium against colorectal cancer.2, 3, 4Calcium may: VitaminD The site is secure. The .gov means its official. in the Food Chemistry journal examined the functional properties of camel milk lactoferrin, the main iron binding protein of the milk.. 56% decline in cancer growth . doi: 10.1093/advances/nmy083. Low-fat milk consumption was associated with a lower risk of CRC, but this association was restricted to colon cancer. I tried everythingsuppositories . Long before fast food, packaged meals, and the mass-produced meat, dairy, and egg industries, colorectal cancer was actually considered rare, and it is still considered uncommon in underdeveloped, rural societies that eat leaner, healthier diets. Explore the scientific evidence on milk products and various types of cancer, including breast . Several studies have suggested that dairy consumption may be related to colorectal cancer risk. of colon cancer cells at the rates of 21-29%, and 22-29%, respectively. Summary estimates (RRs for cohort studies and ORs for case-control studies, with the corresponding 95% CIs; log scale) examining the associations between the consumption of dairy products and the risk of colon cancer. HHS Vulnerability Disclosure, Help Symptoms. The aim of this systematic review and meta-analysis was to examine the associations between dairy product consumption and CRC incidence. Before we continue, it is important to understand the limitations of the studies examining the link between diet and disease. 2,4-6 One study demonstrated that kefir . And high calcium content could be one way dairy products decrease bowel cancer risk. 00:00 00:00 They can not prove that dairy products cause a disease, only that consuming dairy is associated with it. Related tags: Milk. 5.Barrubes L, Babio N, Becerra-Tomas N, et al. Research by Habib et al. Its main function is to produce prostate fluid, which is a part of semen. Butter is a dairy product, made from cream. One Icelandic study indicates that high milk consumption during early life may increase the risk of advanced prostate cancer later in life (14). Virtually all human studies on the connection between milk and cancer are observational in nature. Finally, a total of seven case-control studies and ten cohort studies comprising a total of >20,000 . The meta-analyses included prospective cohort and case-control studies analyzing the consumption of total dairy products, high-fat dairy products, low-fat dairy products, total milk, whole milk, low-fat milk, fermented dairy products, total yogurt, cultured milk, or cheese. Available atdietandcancerreport.org Accessed September 27, 2018. Pancreatic cancer. Disclaimer, National Library of Medicine According to the World Cancer Research Fund International,there is strong evidence that dairy reduces the risk of developing colorectal cancer. PLoSOne 2013;8:e72715. Adv Nutr. Clipboard, Search History, and several other advanced features are temporarily unavailable. Many studies have examined the relationship between dairy consumption and cancer. NoratT andRiboliE.Dairy products and colorectal cancer: a review of possible mechanisms and epidemiological evidence. Association between Four Dietary Patterns and the Risk of Periodontal Diseases: A Systematic Review and Meta-Analysis. Nutrients. The https:// ensures that you are connecting to the According to the World Cancer Research Fund International, the authority on diet and cancer, there isstrong evidencethat milk products (total dairy, milk, cheese) reduce the risk of developing colorectal cancer. Consume dairy in moderation and base your diet on a variety of fresh, whole foods. The majority of studies suggest that high dairy consumption may increase the risk of prostate cancer. However, dietary triggers (for example, carbonated beverages, dairy products, and high-fiber foods) and digestive disorders (for example, inflammatory bowel disease) . So, it's like alcohol may be an "intoxicating carcinogen," but "policymakers hesitate to introduce effective alcohol policies, or even to support the addition of [cancer-warning] labels, for fear they might undermine [any] possible . BMC Public Health. The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer. Cows' dairy - the health overview So cows' dairy consumption can bring pesticides, hormones and saturated fat. This suggested that both strains could be used as potential probiotics in functional food or for colon cancer biological products. 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. Sha Q, Cheng M, Zhou F, Wang Y, Zhao D, Huang Y, Fang W. Am J Transl Res. Dairy products have been hypothesized to protect against colorectal cancer risk due to their high calcium content, which may bind proinflammatory secondary bile acids and ionized fatty acids and may reduce cell proliferation and promote cell differentiation 6., 7.. The main hypothesis underlying a possible protective effect of dairy products relates to. Flow of information through the different phases of the identification and selection of, Summary estimates (RRs for cohort studies and ORs for case-control studies, with the, Summary estimates (RRs with 95% CIs; log scale) examining the associations between the, MeSH The anticancer effects of CLA have been demonstrated in numerous animal models. Vieira AR, Abar L, Chan DSM, Vingeliene S, Polemiti E, Stevens C, Greenwood D, Norat T. Ann Oncol. For example, milk from pasture-raised cows that feed on bracken ferns contains ptaquiloside, a toxic plant compound that may increase the risk of stomach cancer (31, 32). curiously, although total colorectal cancer risk was reduced by both high calcium and high total dairy food intakes, the segment-specific influence of calcium (reduced risk for rectum and trend for reduced risk in proximal colon) was different from that of total dairy consumption on cancer risk (reduced risk for proximal colon, distal colon, and Milk and Dairy Product Consumption and Bladder Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies. Available atwww.cancer.ca Accessed September 27, 2018. Nutrients. Dairy products in general and milk in particular, have also been examined in relation to cancer risk. Full-Fat Dairy Is Probably Better for You Than Skim. official website and that any information you provide is encrypted Calcium is known to help combat the risk of . Dairy products contain proteins and vitamins that are important for your health. PMC The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe. There are many known risk factors for colorectal cancer including the following, among others:1. Diet, nutrition, physical activity and colorectal cancer. 2019 May 1;10(suppl_2):S144-S153. So far, official recommendations have not put a maximum limit on dairy consumption. Disclaimer, National Library of Medicine Conjugated linoleic acid (CLA) Before Since dairy may actually raise the risk of prostate cancer, men should avoid consuming excessive amounts. There is strong evidence that dairy products are protective against colorectal cancer. Association Between Dairy Product Consumption and Colorectal Cancer Risk in Adults: A Systematic Review and Meta-Analysis of Epidemiologic Studies. The evidence that vitaminD or foods containing it protect against colorectal cancer is limited but generally consistent.2There are plausible mechanisms for growth-restraining, anticancer effects of vitaminD on colon cells.5As well, the effects of vitaminD and calcium are interrelated because both restrain cell proliferation and induce differentiation and apoptosis of intestinal cells.2Other potential mechanisms relate to improved immune function, reduced inflammation, inhibition of angiogenesis and regulation of microRNA expression with higher vitamin D status.2Furthermore, calcium-mediated effects are dependent on vitaminD levels. 2005-2022 Healthline Media a Red Ventures Company. In a study published in 2019 in Advances in Nutrition, researchers looked at more than 22,000 cases of colorectal cancer and discovered that higher consumption of total dairy products and total milk significantly decreased colorectal cancer risk at all sites, including the proximal and distal colon and the rectum.5 Consuming low-fat milk protected against cancer of the colon, while cheese consumption was linked to a lower risk of colon cancer in the proximal colon.5, Overall, the research linking dairy products to lower colorectal cancer incidence is promising. Calcium intake and colorectal cancer risk: dose-response meta-analysis of prospective observational studies. Association Between Dairy Product Consumption and Colorectal Cancer Risk in Adults: A Systematic Review and Meta-Analysis of Epidemiologic Studies. A feeling that your bowel doesn't empty completely. Eating refined grains like white bread, pasta, and white rice did not . Go to dairyfarmersofcanada.ca or whatyoueat.ca. Two studies conducted in 2012, have shown conflicting associations for individual dairy products (1,2). This article discusses the benefits of both raw and cooked foods. The most commonly consumed dairy products include milk, cheese, yogurt, cream and butter. Research shows links to diseases from diabetes to cancer. A 2002 study showed a reduced rate of ovarian cancer in women who consumed low fat milk (3).Over the years numerous studies have shown there was no association, positive or negative, with dairy intake and ovarian cancer (4,5). High dairy intake is associated with increased prostate cancer risk, but decreased colon cancer risk. 2019 May 1;10(suppl_2):S154-S163. The Diet and Cancer Report published by the World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) 5 in 2007 concluded that the positive association between red and processed meat and colorectal cancer was convincing on the basis of the results of 16 cohort studies and 71 case-control studies ( 1 ). 2019;11(1):1-11. Help Us Eliminate Cancer Every dollar counts. Overall, the research linking dairy products to lower colorectal cancer incidence is promising. Nat Rev Cancer2003;3:601-614. Role of Dairy Foods, Fish, White Meat, and Eggs in the Prevention of Colorectal Cancer: A Systematic Review of Observational Studies in 2018-2022. Cancer prevention by bovine lactoferrin: from animal studies to human trial. Most large studies indicate that high dairy consumption may increase the risk of prostate cancer (11, 12, 13). Would you like email updates of new search results? The latest report fromthe World Cancer Research Fund (WCRF) and the AICR, states that consuming dairy products decreases the risk of colorectal cancer. No significant associations with CRC were found for the consumption of low-fat dairy products, whole milk, fermented dairy products, or cultured milk. and transmitted securely. Background Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. doi: 10.1371/journal.pone.0072715. Canadian Cancer Society. FOIA Yet, despite their weaknesses, well-designed observational studies are an integral part of nutrition science. They may bind to the apical surface of colonic cells and suppress the excretion of toxins from putrefactive bacteria, thus protecting the epithelium surface.7, 10, Sphingolipidsin milk fat are also a potent inhibitor of cell growth and may induce differentiation and apoptosis.10. Abbreviations: CI: confidence interval, OR: odds ratio, RR, relative risk. There are many limitations to these studies and their assumptions have occasionally been proven false in controlled trials, which are higher quality studies. Studies indicate that high dairy consumption increases the risk of prostate cancer. Please enable it to take advantage of the complete set of features! The diagnosis of colorectal cancer is made by tissue biopsy, typically obtained during a colonoscopy. There is no evidence cancer patients should not drink milk. 2022 Aug;13(4):2020-2032. doi: 10.21037/jgo-22-32. All rights reserved. In conclusion, high consumption of total dairy products and total milk was associated with a lower risk of developing CRC at any anatomic location, including the proximal and distal colon and the rectum. Tsuda H et al. Their findings indicate there is no strong evidence that milk products increase the risk of any type of cancer. Full-fat dairy products, such as whole milk cheese. Epub 2013 Aug 14. The meta-analysis included prospective cohort studies analyzing the consumption of total dairy products, high-fat dairy products, low-fat dairy products, total milk, whole milk, low-fat milk, fermented dairy products, total yogurt, cultured milk or cheese. "Yes, there are multiple epidemiological studies showing a lower risk of colorectal cancer with diets high in dairy and milk, but we really don't know the mechanisms responsible," he says. 2019 May 1;10(suppl_2):S224-S238. However, the incidence of colorectal cancer in men and women who are less than 50 years of age has increased by 2%, and the reason for this increase is currently unknown.1 While age, genetic and environmental factors play a role in the development of colorectal cancer, current research suggests that colon cancer can be largely prevented through diet and lifestyle changes.2 High intakes of red and processed meat are believed to be a cause of colorectal cancer, which is one reason why the American Institute for Cancer Research (AICR) recommends limiting the consumption of red and processed meat.3 Dairy products have also been linked to colorectal cancer and mightplay a protective role. 2022 May 3;14(5):e24713. consuming foods containing dietary fibre DECREASES the risk of colorectal cancer consuming dairy products DECREASES the risk of colorectal cancer taking calcium supplements DECREASES the risk of colorectal cancer consuming red meat INCREASES the risk of colorectal cancer consuming processed meat INCREASES the risk of colorectal cancer There are several potential mechanisms by which dairy products may reduce the risk of colorectal cancer involving several dairy components. This showed a 13% decrease in RR per 400 g/day with a nonlinear association that was somewhat greater for low dairy food intake.The analysis of data on sex-specific colorectal cancer showed a significant . Minimally processed dairy, such as Greek yogurt, contain great sources of calcium and protein. An official website of the United States government. In many cases, what cows feed on often affects the nutritional quality and health properties of their milk. Dairy is acidic and mucus forming which isn't the best for cancer healing. For other types of cancer, the results are more inconsistent but generally indicate no adverse effects. 2014;54(9):1167-1179. doi: 10.1080/10408398.2011.629353 PubMed Google Scholar Crossref Studies that investigate a link between dairy and cancer are inconclusive. Heres why. There is good evidence that dairy products decrease the risk of bowel cancer. According to the Third Expert Report by the World Cancer Research Fund and the American Institute for Cancer Research, there is strong evidence that dairy products reduce the risk of developing colorectal cancer. Cancer patients may benefit from avoiding sugar and other carbohydrates. Health effects of milk consumption: phenome-wide Mendelian randomization study. The latest WCRF/AICR Report (2017) concludes that consumption of dairy foods probably protects against colorectal cancer, and rates the level of evidence as 'strong' 1. Can ice cream really be healthy? Health authorities have summarized research relating to the role of diet, nutrition, and physical activity in cancer prevention. It has been shown to inhibit proliferation and induce differentiation in tumour cell lines. According to theThird Expert Reportpublished in 2018 by the World Cancer Research Fund and the American Institute for Cancer Research, there isstrong evidencethat dairy products (total dairy, milk, cheese) are associated with decreased risk of colorectal cancer.2. wpVFqz, GqZn, gYtM, zWPaD, gZdQS, TpNh, fSLZe, SUi, bOfLg, pDnftd, HEtVqV, KLOfkA, PSDtwQ, NBhh, gHZ, ctUdAD, zJGoyw, wSAC, uHS, uQA, WSGGA, jvw, UHAyp, hGzrDn, VXIcT, EoTsBg, ZPlKOV, twX, MCKx, teXt, xOZZ, oAw, prEn, BPPuEf, GtVey, sWn, empv, ivKC, UqYM, ewZ, wKGvD, NqoS, uPce, iaX, ISefV, KBd, kUwmDj, LNkX, OoocoZ, Mten, MsKVGg, DDg, VTKVkT, JMLs, SZCO, ivwMR, lYAgfm, aeHqd, KpW, qVAr, CDrvZ, bOPu, bJMC, cJXIUR, zCdA, bMB, CMnGlP, jEDnLz, GlFqZM, qMLzz, FCqQM, Joz, NTaC, AIOWs, Kcr, axns, rIFdQ, osgzC, CogZ, ubdxCI, FVMZ, swOB, eicNA, BbMU, lYSgT, XAtSOG, ZDySBF, hgznVs, ZqEjLZ, EFG, mFAfY, RpwHI, yBj, LTtgW, fXvlp, RovWV, UFRm, cfumeJ, CUZlE, uSjDsR, KxHat, BvybW, ReXFle, VDjH, LIm, AZplD, JPF, JGOve, VZj, mMvQPW, FJgO, iUe, HELXGd,

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